Speaker: Dr. Stephen Hecht, ACS Fellow
Where: Cancer and Cardiovascular Research Building (opened 2014)
Address: Biomedical Discovery District, 2231 6th St SE, Minneapolis, MN 55455
Time: Executive meeting at 5 pm, Dinner at 6 pm, Seminar at 7 pm
Cost: $13 in advance, $18 at the door, $5 for students
Menu: Noodles and Company, salad, bread, dessert, pop, water
Meal Ticket: Go to the "Web Store" link to purchase meal reservations through PayPal.
Deadline: Must register by Monday, November 2nd
Abstract: Tobacco products are responsible for approximately 30% of all cancer death in the U.S., and 90% of lung cancer mortality. The carcinogenic tobacco-specific nitrosamines N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are present in all tobacco products and are considered to be important causative factors for tobacco-induced cancer. Metabolism of NNN and NNK in laboratory animals and humans leads to the formation of highly electrophilic diazohydroxide intermediates that react with cellular DNA to form a complex array of products which initiate the carcinogenic process. The metabolites and DNA adducts have been characterized by their spectral properties and by independent synthesis. The metabolism and DNA adduct formation of NNN and NNK are discussed in this presentation.
Information on speaker: http://www.pharmacy.umn.edu/faculty/hecht_stephen/